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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/42922/21
    Transformation of 3-(Furan-2-yl)-1,3-di(het)arylpropan-1-ones to Prop-2-en-1-ones via Oxidative Furan Dearomatization/2-Ene-1,4,7-triones Cyclization
    01-Jul-2021 Research 2021 : July - September
    Roman O Shcherbakov, Diana A Eshmemet’eva, Anton A Merkushev, Igor V Trushkov, Maxim G Uchuskin

    The approach to 3-(furan-2-yl)-1,3-di(het)arylprop-2-en-1-ones based on the oxidative dearomatization of 3-(furan-2-yl)-1,3-di(het)arylpropan-1-ones followed by an unusual cyclization of the formed di(het)aryl-substituted 2-ene-1,4,7-triones has been developed. The cyclization step is related to the Paal–Knorr synthesis, but the furan ring formation is accompanied in this case by a formal shift of the double bond through the formation of a fully conjugated 4,7-hydroxy-2,4,6-trien-1- one system or its surrogate.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Shcherbakov, Roman O., et al. "Transformation of 3-(Furan-2-yl)-1, 3-di (het) arylpropan-1-ones to Prop-2-en-1-ones via Oxidative Furan Dearomatization/2-Ene-1, 4, 7-triones Cyclization." Molecules 26.9 (2021): 2637. https://doi.org/10.3390/molecules26092637 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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